Personalized Biomedical Intervention and Rehabilitation of Autism Spectrum Disorder Patients

Background. Modern scientific research have identified the most important biological components and pathological processes that contribute to the causes and development of an autistic specter disorder (ASD). However, autism management using psychological and pedagogical methods are of greater importance rather than medical examination and treatment. The purpose of the present study was to analyze the dynamics of ASD-related psychoneurological and laboratory indicators during the treatment using biomedical technologies. Materials and methods. The study included 68 children with moderate and severe ASD. In this work, psychopathological, psychometric, clinical, laboratory and statistical methods were used. Results revealed a pro-inflammatory state, heterogeneous changes in metabolic status, endocrine dysfunction with various degrees of impairment compensation. Personalized biomedical intervention helps to reduce the severity of psychoneurological symptoms and improve physical well-being, which is confirmed by laboratory tests. Conclusion. Interventions aimed at eliminating inner factors contributing to homeostasis disorders such as inflammation, metabolic dysfunction and hormonal imbalance contribute to the age- and gender-specific innate behavioral patterns, which results in successful outcomes in terms of normal child development. Keywords: autism spectrum disorder; neuroinflammation; metabolic dysfunction; hormonal imbalance; behavioral patterns; rehabilitation

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