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Capabilities of Molecular Genetic Methods for Effective Hereditary Cancers Detection in Individuals with High Cancer Risk Factors

https://doi.org/10.47619/2713-2617.zm.2023.v.4i2;30-40

Abstract

Russia and other countries report an increase in the incidence of malignant neoplasms, and approximately 10 % of all oncological cases have hereditary background. Molecular genetic testing in patients with diagnosed malignant neoplasms and a suspected hereditary factor will help to select effective modern methods of treatment and prevention of the development of neoplasms of other localizations.
According to the study, 12,6 % of patients had hereditary cancer syndrome, which allowed to administer molecular genetic tests to patients’ relatives. Consequently, it becomes possible to detect hereditary cancer risk factors, improve the efficiency of clinical examination, elaborate and implement programs for prevention and early detection of the disease.

About the Authors

A. B. Semenova
City Clinical Oncological Hospital No. 1 of Moscow Healthcare Department
Russian Federation

Anna B. Semenova – D. Sc. in Medicine, Head of the Center for Pathological Diagnosis and Molecular Genetics

7, corp., 18A, sh. Zagorodnoe, Moscow, 117152



M. M. Byakhova
City Clinical Oncological Hospital No. 1 of Moscow Healthcare Department
Russian Federation

Mariya M. Byakhova – D. Sc. in Medicine, Head of the Genetics Laboratory of Center for Pathological Anatomical Diagnostics and Molecular Genetics

7, corp., 18A, sh. Zagorodnoe, Moscow, 117152



V. N. Galkin
City Clinical Oncological Hospital No. 1 of Moscow Healthcare Department
Russian Federation

Vsevolod N. Galkin – D. Sc. in Medicine, Professor, Chief Physician

7, corp., 18A, sh. Zagorodnoe, Moscow, 117152



S. A. Parts
City Clinical Oncological Hospital No. 1 of Moscow Healthcare Department
Russian Federation

Sergey A. Parts – PhD, Deputy Head Physician

7, corp., 18A, sh. Zagorodnoe, Moscow, 117152



M. V. Makarova
Evogen
Russian Federation

Maria V. Makarova – Geneticist, Head of the Oncogenetics Department

5, str., 20 pr-d 4th Roshchinskij, Moscow, 115162



M. V. Nemtsova
Evogen
Russian Federation

Marina V. Nemtsova – D. Sc. in Biology, Professor, Expert in Oncogenetics, Laboratory Geneticist

5, str., 20 pr-d 4th Roshchinskij, Moscow, 115162



D. K. Chernevskiy
Evogen
Russian Federation

Denis K. Chernevskiy – Geneticist

5, str., 20 pr-d 4th Roshchinskij, Moscow, 115162



O. V. Sagaydak
Evogen
Russian Federation

Olesya V. Sagaydak – PhD, Head of the Scientific and Medical Department

5, str., 20 pr-d 4th Roshchinskij, Moscow, 115162



E. E. Baranova
Evogen
Russian Federation

Elena E. Baranova – PhD, Assistant Professor, Geneticist, Medical Director

5, str., 20 pr-d 4th Roshchinskij, Moscow, 115162



M. S. Belenikin
Evogen
Russian Federation

Maxim S. Belenikin – PhD, Head of the Laboratory

5, str., 20 pr-d 4th Roshchinskij, Moscow, 115162



A. A. Krinitsina
Evogen
Russian Federation

Anastasia A. Krinitsina – PhD, Deputy Head of the Laboratory

5, str., 20 pr-d 4th Roshchinskij, Moscow, 115162



I. E. Khatkov
Loginov Moscow Clinical Scientific and Practical Center of Moscow Healthcare Department
Russian Federation

Igor E. Khatkov – D. Sc. in Medicine, Professor, Chief Specialist in Oncology of Moscow Healthcare Department, Director, Academician of the Russian Academy of Sciences

10, corp., 6, str., 86, Entuziastov sh., Moscow, 111123



N. A. Bodunova
Loginov Moscow Clinical Scientific and Practical Center of Moscow Healthcare Department
Russian Federation

Natalia A. Bodunova – PhD, Gastroenterologist, Head of the Center for Personalized Medicine

10, corp., 6, str., 86, Entuziastov sh., Moscow, 111123



A. M. Danishevich
Loginov Moscow Clinical Scientific and Practical Center of Moscow Healthcare Department
Russian Federation

Anastasia M. Danishevich – Geneticist of the Center for Personalized Medicine

10, corp., 6, str., 86, Entuziastov sh., Moscow, 111123



D. Yu. Kanner
Moscow City Oncological Hospital No. 62 of Moscow Healthcare Department
Russian Federation

Dmitry Yu. Kanner – PhD, Chief Physician

1–30, str., 27, pos. Istra, gorodskoj okrug Krasnogorsk, Moscovskaya obl., Moscow, 143515



N. A. Savelov
Moscow City Oncological Hospital No. 62 of Moscow Healthcare Department
Russian Federation

Nikita A. Savelov – Head of Pathology and Anatomy Department

1–30, str., 27, pos. Istra, gorodskoj okrug Krasnogorsk, Moscovskaya obl., Moscow, 143515



A. V. Shabunin
Botkin City Clinical Hospital of Moscow Healthcare Department
Russian Federation

Alexey V. Shabunin – D. Sc. in Medicine, Professor, Chief Physician, Academician of the Russian Academy of Sciences

5, pr-d 2nd Botkinskij, Moscow, 125284



S. S. Lebedev
Botkin City Clinical Hospital of Moscow Healthcare Department
Russian Federation

Sergey S. Lebedev – PhD, Head of the Outpatient Cancer Care Center

5, pr-d 2nd Botkinskij, Moscow, 125284



D. N. Protsenko
Moscow Multidisciplinary Clinical Center “Kommunarka” of Moscow Healthcare Department
Russian Federation

Denis N. Protsenko – D. Sc. in Medicine, Head

8, Sosenskij Stan ul., pos. Kommunarka, pos. Sosenskoe, Moscow, 108814



S. M. Gadzhieva
Moscow Healthcare Department
Russian Federation

Saida M. Gadzhieva – PhD, Oncologist, Deputy Head

43, per. Oruzhejnyj, Moscow, 127006



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Review

For citations:


Semenova A.B., Byakhova M.M., Galkin V.N., Parts S.A., Makarova M.V., Nemtsova M.V., Chernevskiy D.K., Sagaydak O.V., Baranova E.E., Belenikin M.S., Krinitsina A.A., Khatkov I.E., Bodunova N.A., Danishevich A.M., Kanner D.Yu., Savelov N.A., Shabunin A.V., Lebedev S.S., Protsenko D.N., Gadzhieva S.M. Capabilities of Molecular Genetic Methods for Effective Hereditary Cancers Detection in Individuals with High Cancer Risk Factors. City Healthcare. 2023;4(2):30-40. (In Russ.) https://doi.org/10.47619/2713-2617.zm.2023.v.4i2;30-40

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