The Role of Internal Migration in the Formation of Pathological Reactivity in Adverse Climatic and Geographic Conditions

Background. The study of the migration role in the formation of pathological reactivity in adverse climatic and geographic conditions is of great practical importance for identifying the variety of adaptive capabilities and better understanding the changes that can be applied to regions with greater anthropogenic modification. The goal was to assess the individual reactivity of the cardiovascular system of generally healthy respondents depending on their emotional state in the conditions of climatic and geographic stress. Materials and methods. 346 male respondents with an average age of 31.6 ± 6.0 years participated in the study. The indicators characterizing the functional state of the cardiovascular system were studied and calculated, and the adaptive capabilities of the cardiovascular system were assessed based on the functional changes and emotional well-being. Results. Respondents who have moved from subpolar to polar regions higher SAD, average BP, pulse pressure and cardiac output indicators by 9.5, 7.4, 13.7 and 7.4% respectively, in comparison with respondents living in moderate mid-latitude conditions with p < 0.05. In comparison with the same indicators between individuals who moved from the subpolar and mid-latitude regions to the polar regions, the indicators were higher by 10.6, 7.7, 19.5 and 7.7%, respectively. Double product, myocardial efficiency, and endurance coefficient in respondents who moved from subpolar to polar areas were significantly higher by 26.6, 27.7 and 18%, respectively, compared to individuals living in the mid-latitude regions. In terms of emotional well-being, 66.7% of respondents who moved from subpolar to polar regions showed the highest average level of mental activation. Conclusion. The constant independent migratory factors of generally healthy respondents living in polar regions with adverse climatic and geographic conditions against the background of mid-levels of emotional well-being cause compensatory changes and an adaptive primary pulmonary arterial hypertension, which is typical for northern regions. However, an individual who moved from mid-latitude regions to polar regions experiences negative consequences of migration, as against the background of high mental activation and interest, mid-level emotional state, low level of stress, and high level of comfort, a maladaptive form of primary pulmonary arterial hypertension can develop.

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